All that's left is planning and execution. I think the comparison with Dark Souls is actually pretty good, both games are relatively easy once you're familiar with the enemies, levels and mechanics. If you can't handle that then I've got a message for you. Headshot is the name of the game in Misery, everything else is a waste of ammo. Same goes for enemies, a lot of them wear armor, especially those in higher 'level' areas. Don't expect to stop a bullet with your trenchcoat, but an upgraded combat suit just might do the job.
This goes for enemies as well as your character. Once that's done you can retreat a little and flank the enemy - I was actually surprised this was possible, until I've seen it with my own eyes I was convinced that enemies in STALKER have xray vision, but they don't, at least not in Misery.Ģ) Armor counts for something in Misery. This way you can quickly drop 3 or more enemies, more if you got range advantage.